Indian Journal of Anaesthesia

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 62  |  Issue : 3  |  Page : 182--187

Role of dexmedetomidine as an anaesthetic adjuvant in breast cancer surgery as a day-care procedure: A randomised controlled study


Rekha Das1, Rajat Kumar Das1, Sushrita Sahoo2, Suchismita Nanda3 
1 Department of Anaesthesiology, AHRCC, Cuttack, Odisha, India
2 Department of Anaesthesiology, SCB Medical College, Cuttack, Odisha, India
3 Department of Emergency Medicine, AHRCC, Cuttack, Odisha, India

Correspondence Address:
Dr. Rekha Das
Shanti Hospital, Patnaik Colony, Thoria Sahi, Cuttack, Odisha
India

Background and Aims: Breast cancer surgery can be carried out as day-care procedure to increase patient turnover, decrease disease progression and financial burden. The present study was carried out to assess the role of dexmedetomidine in breast cancer surgery as a day-care procedure. Methods: This prospective randomised, double-blind study was carried out on 100 patients screened for day-care breast cancer surgery. They were divided into two groups of 50 each; who received either normal saline (Group NS) or 0.6 μg/kg/h dexmedetomidine (Group D) infusion from 10 min before induction until skin closure. All patients were given general anaesthesia. The incidence of discharge, post-operative pain (POP), average rescue analgesia (fentanyl) required and side effects were noted. Statistical analysis was performed using Student's t-test and Chi-square test. Results: Incidence of discharge in group NS was 60% compared to 88% in Group D (P = 0.001). Average rescue analgesia requirement by group NS was 136.07 ± 43.06 μg, whereas it was 77.5 ± 29.86 μg in Group D (P = 0.01). The incidence of POP in 6 h and within 2 h of expected discharge time in Group NS was 56% and 28%, respectively, and in Group D, it was 8% in both the periods (P < 0.001 and 0.01). Side effects such as post-operative nausea, vomiting and bleeding were encountered in eight and two patients, respectively, in Group NS and two and one patients, respectively, in Group D. Conclusion: Dexmedetomidine as an anaesthetic adjuvant makes breast cancer surgery feasible on day-care basis.


How to cite this article:
Das R, Das RK, Sahoo S, Nanda S. Role of dexmedetomidine as an anaesthetic adjuvant in breast cancer surgery as a day-care procedure: A randomised controlled study.Indian J Anaesth 2018;62:182-187


How to cite this URL:
Das R, Das RK, Sahoo S, Nanda S. Role of dexmedetomidine as an anaesthetic adjuvant in breast cancer surgery as a day-care procedure: A randomised controlled study. Indian J Anaesth [serial online] 2018 [cited 2021 Jan 22 ];62:182-187
Available from: https://www.ijaweb.org/article.asp?issn=0019-5049;year=2018;volume=62;issue=3;spage=182;epage=187;aulast=Das;type=0