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Year : 2018  |  Volume : 62  |  Issue : 2  |  Page : 156  

Dextrose for post-operative nausea and vomiting prophylaxis

Department of Anesthesiology, Rhode Island Hospital, Providence, Rhode Island 02903, USA

Date of Web Publication12-Feb-2018

Correspondence Address:
Dr. Mark C Kendall
Department of Anesthesiology, Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, Rhode Island 02818
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ija.IJA_779_17

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How to cite this article:
Castro-Alves LJ, Kendall MC. Dextrose for post-operative nausea and vomiting prophylaxis. Indian J Anaesth 2018;62:156

How to cite this URL:
Castro-Alves LJ, Kendall MC. Dextrose for post-operative nausea and vomiting prophylaxis. Indian J Anaesth [serial online] 2018 [cited 2021 Apr 18];62:156. Available from: https://www.ijaweb.org/text.asp?2018/62/2/156/225228


We read with great interest the article of Firouzian et al. in a recent issue of this journal.[1] The authors examined 150 patients and concluded that administration of intravenous dextrose before anaesthesia induction may be recommended as an effective method for the prophylaxis of post-operative nausea and vomiting after laparoscopic cholecystectomy. The authors should be congratulated for performing a well-designed trial in an important topic in perioperative medicine.[2],[3]

Although the study of Firouzian et al. was well designed, there are some concerns regarding their randomised trial that needs to be clarified to determine the validity of the study findings. First, we could not identify if the authors used agents for post-operative nausea and vomiting prophylaxis that are currently considered the standard of care.[4],[5] Second, it would be important to present the post-operative opioid consumption by study groups, as this can significantly alter the primary outcome.[6] Finally, the authors excluded patients who were at high risk for post-operative nausea and vomiting; and therefore, it is likely that their findings are not generalisable to other patients beyond the patients included in this study.

We would welcome some comments to address the aforementioned issues. This would help to further validate the findings of this important study.

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Conflicts of interest

There are no conflicts of interest.

   References Top

Firouzian A, Kiasari AZ, Godazandeh G, Baradari AG, Alipour A, Taheri A, et al. The effect of intravenous dextrose administration for prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy: A double-blind, randomised controlled trial. Indian J Anaesth 2017;61:803-10.  Back to cited text no. 1
  [Full text]  
Mishra A, Pandey RK, Sharma A, Darlong V, Punj J, Goswami D, et al. Is perioperative administration of 5% dextrose effective in reducing the incidence of PONV in laparoscopic cholecystectomy? A randomized control trial. J Clin Anesth 2017;40:7-10.  Back to cited text no. 2
Tateosian V, Gan TJ. Another quest for the holy grail of abolishing post operative nausea and vomiting. J Clin Anesth 2017;41:58-9.  Back to cited text no. 3
Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, et al. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2014;118:85-113.  Back to cited text no. 4
Koyuncu O, Leung S, You J, Oksar M, Turhanoglu S, Akkurt C, et al. The effect of ondansetron on analgesic efficacy of acetaminophen after hysterectomy: A randomized double blinded placebo controlled trial. J Clin Anesth 2017;40:78-83.  Back to cited text no. 5
Goyal R, Mittal G, Yadav AK, Sethi R, Chattopadhyay A. Adductor canal block for post-operative analgesia after simultaneous bilateral total knee replacement: A randomised controlled trial to study the effect of addition of dexmedetomidine to ropivacaine. Indian J Anaesth 2017;61:903-9.  Back to cited text no. 6
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