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Year : 2014  |  Volume : 58  |  Issue : 3  |  Page : 323-326

Emphysematous pancreatitis predisposed by Olanzapine

1 Department of Anesthesia and Critical Care (Trauma Centre), JPNA Trauma Centre, AIIMS, New Delhi, India
2 Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Department of General Medicine, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India

Correspondence Address:
Dr. Sukhen Samanta
17, Dr. A. N. Paul Lane, Bally, Howrah - 711 201, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5049.135049

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A 32-year-old male presented to our intensive care unit with severe abdominal pain and was diagnosed as acute pancreatitis after 2 months of olanzapine therapy for bipolar disorder. His serum lipase was 900 u/L, serum triglyceride 560 mg/dL, and blood sugar, fasting and postprandial were 230 and 478 mg/dL, respectively on admission. Contrast enhanced computed tomography (CECT) of abdomen was suggestive of acute pancreatitis. Repeat CECT showed gas inside pancreas and collection in peripancreatic area and patient underwent percutaneous drainage and antibiotics irrigation through the drain into pancreas. We describe the rare case of emphysematous pancreatitis due to development of diabetes, hypertriglyceridemia and immunosuppression predisposed by short duration olanzapine therapy.

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