• Users Online: 2621
  • Print this page
  • Email this page
CLINICAL INVESTIGATION
Year : 2010  |  Volume : 54  |  Issue : 2  |  Page : 127-131

L-type calcium channel blockers, morphine and pain: Newer insights


Department of Anatomy, All India Institute of Medical Sciences, New Delhi - 110 029, India

Correspondence Address:
S Basu Ray
Department of Anatomy, All India Institute of Medical Sciences, New Delhi - 110 029
India
Login to access the Email id

Source of Support: The Indian Council of Medical Research, New Delhi, through an Extramural Research Grant (I-570) for the time period 2008 - 2011, Conflict of Interest: None


DOI: 10.4103/0019-5049.63652

Rights and Permissions

Earlier, we had reported that co-administration of opioids and L-type calcium channel blockers (L-CCBs) like diltiazem could prove useful in the treatment of cancer pain. Much of this report was based upon earlier published work involving animal models of pain exposed to brief periods of noxious radiant heat without any tissue injury. However, pain in clinical situations usually result from tissue injury. Thus, the aim of the current investigation was to study the analgesic effect of this combination of drugs in the rat formalin test which is associated with actual tissue injury. Wistar rats (n=60) received either L-CCB (nifedipine/nimodipine/verapamil/diltiazem i.p.) or morphine (s.c.) or both drugs. The formalin test was done 30 min after morphine or placebo injection. The naloxone reversal test was also done. Administration of L-CCBs alone, particularly diltiazem, increased pain in the formalin test. In contrast, co-administration of these L-CCBs with morphine led to decreased pain response, though statistically significant decrease was noted only with nimodipine + morphine. Naloxone reversed this analgesic effect, indicating that it was primarily an opioid-mediated effect. The results show that administration of L-CCBs alone may prove counterproductive in the therapeutic management of pain (anti-analgesic effect). However, co-administration of both drugs (morphine and nimodipine) in quick succession could lead to adequate pain relief.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3304    
    Printed184    
    Emailed1    
    PDF Downloaded588    
    Comments [Add]    
    Cited by others 12    

Recommend this journal